AKR1A1

Across TCGA cell cohorts, AKR1A1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AKR1A1-associated genes across cancer lineages are ASZ1, OR10T2, and OR10R2. Each is linked with AKR1A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AKR1A1-to-partner and partner-to-AKR1A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASZ1 grouped by AKR1A1-low versus AKR1A1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR1A1→partner) and Y-score (partner→AKR1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ASZ1 →	+0.132	+4.152	<.001	.009	3	1
BLOOD_Leukemia	OR10T2 →	+0.743	+4.276	<.001	.007	3	1
BLOOD_Leukemia	OR10R2 →	+1.907	+4.551	<.001	.004	3	1
LUNG_SCLC	GDF3 →	+0.013	+5.643	<.001	.002	3	1
OVARY	RBMY1A1 →	+0.143	+5.807	<.001	.001	3	1
BLOOD_Leukemia	DIRAS2 →	+0.152	+4.087	<.001	.009	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

ASZ1 by AKR1A1 expression — BLOOD_Leukemia

Explore this box plot interactively →