AKR1A1

Across TCGA cell cohorts, AKR1A1 mutation is significantly associated with the mutation status of many other genes, with 2,459 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AKR1A1-associated genes across cancer lineages are CAST, ITGB2, and GBP4. Each is linked with AKR1A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both AKR1A1-to-partner and partner-to-AKR1A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CAST grouped by AKR1A1-low versus AKR1A1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR1A1→partner) and Y-score (partner→AKR1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CAST →	+5.014	+5.584	.003	.003	1	3
OVARY	ITGB2 →	+5.415	+5.415	.004	.004	1	3
BLOOD_Lymphoma	GBP4 →	+5.014	+5.584	.003	.003	1	3
BLOOD_Lymphoma	YY1AP1 →	+4.014	+4.969	.008	.008	1	3
BLOOD_Lymphoma	ANKRD55 →	+6.014	+6.014	.001	.001	1	3
UPPER_AERODIGESTIVE_TRACT	PIK3CD →	+4.392	+4.954	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,459 associations by consensus.

CAST by AKR1A1 expression — BLOOD_Lymphoma

Explore this box plot interactively →