AKNAD1

Across TCGA patient cohorts, AKNAD1 mutation is significantly associated with the RNA expression of many other genes, with 3,218 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKNAD1-associated genes across cancer lineages are ZNF280B, TM2D3, and KIF18B. Each is linked with AKNAD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both AKNAD1-to-partner and partner-to-AKNAD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF280B grouped by AKNAD1-low versus AKNAD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKNAD1→partner) and Y-score (partner→AKNAD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZNF280B →	+0.461	+1.688	<.001	<.001	3	3
UCEC	TM2D3 →	+0.252	+1.625	.005	.005	3	3
UCEC	KIF18B →	+0.682	+1.895	<.001	<.001	3	3
UCEC	COX15 →	+0.322	+1.979	.001	.002	3	3
UCEC	INCENP →	+0.472	+1.768	.002	.003	3	3
UCEC	CCNB2 →	+0.618	+1.874	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,218 associations by consensus.

ZNF280B by AKNAD1 expression — UCEC

Explore this box plot interactively →