AKNAD1

Across TCGA cell cohorts, AKNAD1 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AKNAD1-associated genes across cancer lineages are BRDT, GPR174, and OR2K2. Each is linked with AKNAD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AKNAD1-to-partner and partner-to-AKNAD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BRDT grouped by AKNAD1-low versus AKNAD1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKNAD1→partner) and Y-score (partner→AKNAD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BRDT →	+0.155	+3.906	<.001	.002	3	1
LARGE_INTESTINE	GPR174 →	+0.030	+3.791	<.001	.007	3	1
STOMACH	OR2K2 →	+0.043	+4.432	<.001	.003	3	1
BLOOD_Leukemia	TCF21 →	+0.011	+4.705	<.001	.003	3	1
BLOOD_Leukemia	OR9G1 →	+0.304	+4.874	<.001	.002	3	1
BLOOD_Leukemia	TMEM132C →	+1.096	+4.551	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

BRDT by AKNAD1 expression — LARGE_INTESTINE

Explore this box plot interactively →