AKNA

Across TCGA pan-cancer cohorts, AKNA mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated AKNA data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher AKNA mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated AKNA expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD, PDAC, and HNSC are the cancer types where AKNA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	II,III,IV	0.893	0.331	.004	11	view →
PDAC	OS	Quartile	All	1.000	0.767	.010	5	view →
HNSC	DFS	Tertile	All	0.753	0.554	.047	1	view →
LSCC	DFS	Tertile	II,III,IV	0.490	0.772	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

AKNA–LUAD (OS)

Open the LUAD breakdown →