AKIRIN2

Across TCGA patient cohorts, AKIRIN2 mutation is significantly associated with the RNA expression of many other genes, with 824 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKIRIN2-associated genes across cancer lineages are RN7SKP57, MTND5P35, and CDRT15P7. Each is linked with AKIRIN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AKIRIN2-to-partner and partner-to-AKIRIN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP57 grouped by AKIRIN2-low versus AKIRIN2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKIRIN2→partner) and Y-score (partner→AKIRIN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RN7SKP57 →	+0.282	+4.409	<.001	.006	3	1
CESC	MTND5P35 →	+0.023	+4.539	<.001	.008	3	1
CESC	CDRT15P7 →	+0.073	+4.669	<.001	.007	3	1
CESC	MIR6071 →	+0.491	+4.320	.004	.007	3	1
UCEC	RPS10-NUDT3 →	+0.350	+3.700	<.001	.001	3	1
UCEC	CCL5 →	+1.189	+3.338	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 824 associations by consensus.

RN7SKP57 by AKIRIN2 expression — CESC

Explore this box plot interactively →