AKIRIN2

Across TCGA patient cohorts, AKIRIN2 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKIRIN2-associated genes across cancer lineages are ASNS, eEF2, and ERK2. Each is linked with AKIRIN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AKIRIN2-to-partner and partner-to-AKIRIN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by AKIRIN2-low versus AKIRIN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKIRIN2→partner) and Y-score (partner→AKIRIN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.419	+3.000	.020	.036	3	2
UCEC	eEF2 →	+0.506	+2.321	.004	.035	3	1
UCEC	ERK2 →	+0.281	+2.321	.003	.035	3	1
UCEC	FOXO3a_pS318_S321 →	-0.129	-2.312	.039	.034	3	1
UCEC	JNK_pT183_Y185 →	-0.268	-2.999	.001	.035	3	1
UCEC	Ku80 →	+0.432	+3.472	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

ASNS by AKIRIN2 expression — UCEC

Explore this box plot interactively →