AKIRIN2

Across TCGA cell cohorts, AKIRIN2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,325 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AKIRIN2-associated GO terms across cancer lineages are Nuclear protein quality control by the ubiquitin-proteasome system, Phosphatidylinositol biosynthetic process, and Hair follicle placode formation. Each is linked with AKIRIN2 in more than 19 cancer types. Because this analysis shows association rather than direction, both AKIRIN2-to-partner and partner-to-AKIRIN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear protein quality control by the ubiquitin-proteasome system grouped by AKIRIN2-low versus AKIRIN2-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AKIRIN2→partner) and Y-score (partner→AKIRIN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Nuclear protein quality control by the ubiquitin-proteasome system →	+0.160	+0.739	<.001	.002	3	20
PANCREAS	Phosphatidylinositol biosynthetic process →	+0.050	+0.599	.003	.006	3	12
SOFT_TISSUE	Hair follicle placode formation →	+0.082	+0.627	<.001	<.001	3	12
BREAST	Regulation of transcription initiation by RNA polymerase II →	+0.068	+0.822	<.001	<.001	3	11
BREAST	Regulation of DNA-templated transcription initiation →	+0.063	+0.712	<.001	<.001	3	11
LUNG_SCLC	Positive regulation of DNA-templated transcription initiation →	+0.067	+0.614	.002	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,325 associations by consensus.

Nuclear protein quality control by the ubiquitin-proteasome system by AKIRIN2 expression — LIVER

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