AKAP9

Across TCGA patient cohorts, AKAP9 mutation is significantly associated with the RNA expression of many other genes, with 7,517 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKAP9-associated genes across cancer lineages are UQCRC1, PPM1G, and NARF. Each is linked with AKAP9 in more than 4 cancer types. Because this analysis shows association rather than direction, both AKAP9-to-partner and partner-to-AKAP9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UQCRC1 grouped by AKAP9-low versus AKAP9-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP9→partner) and Y-score (partner→AKAP9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	UQCRC1 →	+0.358	+2.727	.003	.003	3	5
UCEC	PPM1G →	+0.274	+1.241	<.001	<.001	3	5
UCEC	NARF →	+0.324	+1.346	<.001	<.001	3	5
UCEC	CDCA5 →	+0.504	+1.251	<.001	<.001	3	5
COAD	SKA1 →	+0.776	+2.515	<.001	.001	3	5
COAD	PKN3 →	+0.624	+2.000	<.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,517 associations by consensus.

UQCRC1 by AKAP9 expression — LUAD

Explore this box plot interactively →