AKAP9

Across TCGA patient cohorts, AKAP9 mutation is significantly associated with the total protein of many other genes, with 91 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKAP9-associated genes across cancer lineages are TFRC, ATM, and mTOR_pS2448. Each is linked with AKAP9 in more than 3 cancer types. Because this analysis shows association rather than direction, both AKAP9-to-partner and partner-to-AKAP9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by AKAP9-low versus AKAP9-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP9→partner) and Y-score (partner→AKAP9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TFRC →	+0.403	+3.013	.036	.019	3	4
COAD	ATM →	-0.432	-2.321	.002	.032	3	4
BLCA	mTOR_pS2448 →	-0.148	-2.321	.004	.005	3	4
COAD	GAPDH →	+0.637	+3.321	<.001	.009	3	4
LUAD	PAI-1 →	+0.910	+3.321	.002	.009	2	4
LUAD	PDCD4 →	-0.539	-3.000	.003	.034	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 91 associations by consensus.

TFRC by AKAP9 expression — BRCA

Explore this box plot interactively →