AKAP9

Across TCGA cell cohorts, AKAP9 mutation is significantly associated with the RNA expression of many other genes, with 612 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AKAP9-associated genes across cancer lineages are C3orf22, PLD6, and DPM3. Each is linked with AKAP9 in more than 2 cancer types. Because this analysis shows association rather than direction, both AKAP9-to-partner and partner-to-AKAP9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C3orf22 grouped by AKAP9-low versus AKAP9-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP9→partner) and Y-score (partner→AKAP9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	C3orf22 →	+0.034	+3.765	.006	.003	3	3
OVARY	PLD6 →	+0.709	+3.321	.006	.005	3	3
BLOOD_Leukemia	DPM3 →	+0.616	+3.614	.004	<.001	3	3
CNS	TNP2 →	+0.012	+2.736	<.001	.008	3	3
LARGE_INTESTINE	SLC25A51 →	+0.467	+2.459	.001	.003	3	3
LARGE_INTESTINE	C9orf72 →	+0.557	+1.754	.003	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 612 associations by consensus.

C3orf22 by AKAP9 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →