AKAP6

Across TCGA pan-cancer cohorts, AKAP6 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated AKAP6 data layer compared with 22 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher AKAP6 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated AKAP6 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

HNSC, GBM, and UCEC are the cancer types where AKAP6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	III,IV	0.499	0.941	.001	25	view →
GBM	OS	Tertile	All	0.922	0.691	<.001	15	view →
UCEC	OS	Median	All	0.857	0.976	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

AKAP6–HNSC (OS)

Open the HNSC breakdown →