AKAP6

Across TCGA patient cohorts, AKAP6 mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKAP6-associated genes across cancer lineages are PCNA, Caspase-7-cleavedD198, and FOXO3a_pS318_S321. Each is linked with AKAP6 in more than 3 cancer types. Because this analysis shows association rather than direction, both AKAP6-to-partner and partner-to-AKAP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by AKAP6-low versus AKAP6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP6→partner) and Y-score (partner→AKAP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.161	+1.459	.005	.001	3	4
COAD	Caspase-7-cleavedD198 →	+1.056	+3.095	<.001	<.001	3	4
BLCA	FOXO3a_pS318_S321 →	-0.109	-3.584	.029	.002	3	3
STAD	Cyclin-E2 →	+0.139	+3.021	.014	.017	3	3
SKCM	eEF2 →	+0.213	+1.054	.023	.027	3	3
COAD	Smad4 →	+0.124	+2.459	.009	.017	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

PCNA by AKAP6 expression — UCEC

Explore this box plot interactively →