AKAP6

Across TCGA cell cohorts, AKAP6 mutation is significantly associated with the RNA expression of many other genes, with 577 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AKAP6-associated genes across cancer lineages are HBS1L, APTX, and GID4. Each is linked with AKAP6 in more than 2 cancer types. Because this analysis shows association rather than direction, both AKAP6-to-partner and partner-to-AKAP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HBS1L grouped by AKAP6-low versus AKAP6-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP6→partner) and Y-score (partner→AKAP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HBS1L →	+0.693	+3.614	.004	<.001	3	3
BLOOD_Leukemia	APTX →	+0.397	+2.548	.003	.006	3	2
BLOOD_Leukemia	GID4 →	+0.496	+2.489	.006	.007	3	2
BLOOD_Leukemia	ATAD2 →	+0.712	+3.614	.005	<.001	3	2
BLOOD_Leukemia	MIEF2 →	+0.658	+3.321	<.001	.005	3	2
BLOOD_Leukemia	NIPSNAP1 →	+0.703	+3.263	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 577 associations by consensus.

HBS1L by AKAP6 expression — BLOOD_Leukemia

Explore this box plot interactively →