AKAP5

Across TCGA pan-cancer cohorts, AKAP5 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated AKAP5 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher AKAP5 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated AKAP5 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

LUAD, HNSC, and CCRCC are the cancer types where AKAP5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	II,III,IV	0.252	0.751	.016	14	view →
HNSC	DFS	Median	II,III,IV	0.407	0.974	.045	4	view →
CCRCC	DFS	Tertile	All	0.460	1.000	.045	2	view →
GBM	DFS	Quartile	All	0.908	0.734	.027	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

AKAP5–LUAD (DFS)

Open the LUAD breakdown →