AKAP5

Across TCGA patient cohorts, AKAP5 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKAP5-associated genes across cancer lineages are Bak, GAPDH, and JNK_pT183_Y185. Each is linked with AKAP5 in more than 2 cancer types. Because this analysis shows association rather than direction, both AKAP5-to-partner and partner-to-AKAP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bak grouped by AKAP5-low versus AKAP5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP5→partner) and Y-score (partner→AKAP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bak →	+0.254	+2.459	.006	.018	3	3
COAD	GAPDH →	+0.800	+3.008	.002	.019	3	2
COAD	JNK_pT183_Y185 →	-0.269	-2.991	.047	.036	3	2
UCEC	STAT3_pY705 →	-0.444	-2.807	<.001	.002	3	2
UCEC	Smad3 →	+0.177	+2.906	.001	.001	3	2
UCEC	ASNS →	+0.271	+1.700	.046	.042	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

Bak by AKAP5 expression — UCEC

Explore this box plot interactively →