AKAP5

Across TCGA cell cohorts, AKAP5 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,820 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AKAP5-associated GO terms across cancer lineages are DNA-templated DNA replication maintenance of fidelity, Positive regulation of double-strand break repair, and Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery. Each is linked with AKAP5 in more than 13 cancer types. Because this analysis shows association rather than direction, both AKAP5-to-partner and partner-to-AKAP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated DNA replication maintenance of fidelity grouped by AKAP5-low versus AKAP5-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP5→partner) and Y-score (partner→AKAP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	DNA-templated DNA replication maintenance of fidelity →	+0.104	+0.614	.003	.001	3	14
LIVER	Positive regulation of double-strand break repair →	+0.064	+1.133	<.001	<.001	3	14
BONE	Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery →	+0.148	+1.019	<.001	<.001	2	14
LUNG_NSCLC_LUSC	Cell cycle G1/S phase transition →	+0.066	+0.582	.001	.001	3	13
BONE	Protein sumoylation →	+0.081	+1.021	<.001	.001	3	13
OVARY	Positive regulation of DNA repair →	+0.060	+0.641	<.001	.007	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,820 associations by consensus.

DNA-templated DNA replication maintenance of fidelity by AKAP5 expression — OESOPHAGUS

Explore this box plot interactively →