AKAP4

Across TCGA patient cohorts, AKAP4 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,857 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible AKAP4-associated GO terms across cancer lineages are tRNA metabolic process, tRNA processing, and Response to topologically incorrect protein. Each is linked with AKAP4 in more than 8 cancer types. Because this analysis shows association rather than direction, both AKAP4-to-partner and partner-to-AKAP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, tRNA metabolic process grouped by AKAP4-low versus AKAP4-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP4→partner) and Y-score (partner→AKAP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	tRNA metabolic process →	+0.055	+0.192	<.001	<.001	3	9
STAD	tRNA processing →	+0.054	+0.187	<.001	<.001	3	9
UCS	Response to topologically incorrect protein →	+0.045	+0.579	.002	.006	2	9
ESCA	Phosphatidylinositol phosphate biosynthetic process →	+0.052	+0.109	<.001	.002	2	9
UCS	Regulation of macroautophagy →	+0.043	+0.525	<.001	.007	3	8
UCS	Negative regulation of transmembrane transport →	+0.039	+0.674	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,857 associations by consensus.

tRNA metabolic process by AKAP4 expression — STAD

Explore this box plot interactively →