AKAP4

Across TCGA patient cohorts, AKAP4 mutation is significantly associated with the RNA expression of many other genes, with 4,490 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKAP4-associated genes across cancer lineages are CDT1, PRRT2, and KLC2. Each is linked with AKAP4 in more than 3 cancer types. Because this analysis shows association rather than direction, both AKAP4-to-partner and partner-to-AKAP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDT1 grouped by AKAP4-low versus AKAP4-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP4→partner) and Y-score (partner→AKAP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CDT1 →	+0.883	+3.718	.002	<.001	3	4
UCEC	PRRT2 →	-0.391	-1.563	<.001	<.001	3	4
UCEC	KLC2 →	+0.366	+1.933	<.001	<.001	3	4
UCEC	TCOF1 →	+0.307	+1.659	.001	.001	3	4
UCEC	DCPS →	+0.374	+1.936	<.001	<.001	3	4
UCEC	CCNB1 →	+0.518	+1.750	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,490 associations by consensus.

CDT1 by AKAP4 expression — LUAD

Explore this box plot interactively →