AKAP4

Across TCGA cell cohorts, AKAP4 mutation is significantly associated with the mutation status of many other genes, with 1,085 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible AKAP4-associated genes across cancer lineages are OR10AG1, DOCK4, and LAMA2. Each is linked with AKAP4 in more than 3 cancer types. Because this analysis shows association rather than direction, both AKAP4-to-partner and partner-to-AKAP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10AG1 grouped by AKAP4-low versus AKAP4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP4→partner) and Y-score (partner→AKAP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR10AG1 →	+6.321	+6.321	.001	.001	1	4
LUNG_NSCLC_LUAD	DOCK4 →	+2.924	+4.334	.006	.006	1	4
SKIN	LAMA2 →	+2.362	+2.943	.008	.008	1	4
BLOOD_Leukemia	EBF1 →	+4.000	+5.050	.008	.008	1	4
BLOOD_Lymphoma	DCAF4L2 →	+3.969	+3.969	.002	.002	1	3
LUNG_NSCLC_LUAD	TRMT2B →	+5.339	+4.772	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,085 associations by consensus.

OR10AG1 by AKAP4 expression — BLOOD_Leukemia

Explore this box plot interactively →