Across TCGA patient cohorts, AKAP17A mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKAP17A-associated genes across cancer lineages are Myosin-IIa_pS1943, 14-3-3_beta, and eEF2. Each is linked with AKAP17A in more than 2 cancer types. Because this analysis shows association rather than direction, both AKAP17A-to-partner and partner-to-AKAP17A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP17A→partner) and Y-score (partner→AKAP17A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Myosin-IIa_pS1943 →	+0.138	+1.527	.049	.009	3	3
UCEC	14-3-3_beta →	-0.085	-1.973	.013	.029	3	1
UCEC	eEF2 →	+0.244	+1.874	.045	.049	3	1
UCEC	eIF4E →	+0.253	+2.523	<.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.143	-1.906	<.001	.015	3	1
UCEC	ERK2 →	+0.188	+2.999	.004	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Exploration

AKAP17A survival (RNA) · tumor vs normal (RNA) · all AKAP17A data types