AKAP13

Across TCGA patient cohorts, AKAP13 mutation is significantly associated with the RNA expression of many other genes, with 7,807 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKAP13-associated genes across cancer lineages are MRPL39, SEC13, and HSBP1L1. Each is linked with AKAP13 in more than 4 cancer types. Because this analysis shows association rather than direction, both AKAP13-to-partner and partner-to-AKAP13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL39 grouped by AKAP13-low versus AKAP13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP13→partner) and Y-score (partner→AKAP13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPL39 →	+0.423	+1.502	<.001	<.001	3	5
SKCM	SEC13 →	+0.355	+2.854	.002	.001	3	5
COAD	HSBP1L1 →	+0.576	+3.247	<.001	<.001	3	5
UCEC	PHF5A →	+0.512	+2.530	<.001	<.001	3	5
UCEC	NDUFB3 →	+0.314	+1.811	<.001	<.001	3	5
STAD	CKS2 →	+0.899	+3.618	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,807 associations by consensus.

MRPL39 by AKAP13 expression — UCEC

Explore this box plot interactively →