AKAP13

Across TCGA cell cohorts, AKAP13 mutation is significantly associated with the RNA expression of many other genes, with 1,282 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AKAP13-associated genes across cancer lineages are IQCK, TXN2, and ACBD5. Each is linked with AKAP13 in more than 2 cancer types. Because this analysis shows association rather than direction, both AKAP13-to-partner and partner-to-AKAP13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCK grouped by AKAP13-low versus AKAP13-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP13→partner) and Y-score (partner→AKAP13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IQCK →	+0.602	+2.489	.002	.007	3	3
LARGE_INTESTINE	TXN2 →	+0.460	+3.389	.003	.001	3	2
LARGE_INTESTINE	ACBD5 →	+0.633	+3.321	.007	.002	3	2
LARGE_INTESTINE	MED31 →	+0.515	+2.158	.008	.004	2	3
LARGE_INTESTINE	CILK1 →	+0.584	+3.321	.008	.002	3	2
LARGE_INTESTINE	TTC19 →	+0.687	+2.850	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,282 associations by consensus.

IQCK by AKAP13 expression — BLOOD_Leukemia

Explore this box plot interactively →