AKAP12

Across TCGA patient cohorts, AKAP12 mutation is significantly associated with the RNA expression of many other genes, with 6,605 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKAP12-associated genes across cancer lineages are MIR3163, FXYD6P3, and RNA5SP161. Each is linked with AKAP12 in more than 2 cancer types. Because this analysis shows association rather than direction, both AKAP12-to-partner and partner-to-AKAP12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3163 grouped by AKAP12-low versus AKAP12-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP12→partner) and Y-score (partner→AKAP12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	MIR3163 →	+0.456	+4.672	<.001	.004	3	3
HNSC	FXYD6P3 →	+0.058	+3.924	<.001	.001	3	3
HNSC	RNA5SP161 →	+0.186	+3.090	<.001	.008	3	3
HNSC	RNA5SP72 →	+0.262	+3.929	<.001	<.001	3	3
STAD	RNU6-246P →	+0.284	+2.782	<.001	<.001	3	3
CESC	RN7SL283P →	+0.068	+5.263	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,605 associations by consensus.

MIR3163 by AKAP12 expression — READ

Explore this box plot interactively →