AKAP12

Across TCGA cell cohorts, AKAP12 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,691 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible AKAP12-associated GO terms across cancer lineages are Fibroblast activation, Positive regulation of fibroblast migration, and Positive regulation of focal adhesion assembly. Each is linked with AKAP12 in more than 12 cancer types. Because this analysis shows association rather than direction, both AKAP12-to-partner and partner-to-AKAP12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibroblast activation grouped by AKAP12-low versus AKAP12-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP12→partner) and Y-score (partner→AKAP12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Fibroblast activation →	+0.119	+2.054	<.001	<.001	3	13
URINARY_TRACT	Positive regulation of fibroblast migration →	+0.136	+3.221	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Positive regulation of focal adhesion assembly →	+0.166	+2.668	<.001	<.001	3	11
LIVER	Regulation of protein kinase C signaling →	+0.215	+3.061	<.001	<.001	3	11
LARGE_INTESTINE	Positive regulation of receptor localization to synapse →	+0.181	+2.812	<.001	<.001	3	11
URINARY_TRACT	Regulation of glial cell apoptotic process →	+0.159	+3.503	.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,691 associations by consensus.

Fibroblast activation by AKAP12 expression — BONE

Explore this box plot interactively →