AKAP12

Across TCGA cell cohorts, AKAP12 mutation is significantly associated with the RNA expression of many other genes, with 616 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AKAP12-associated genes across cancer lineages are C6orf118, SPO11, and GPR152. Each is linked with AKAP12 in more than 1 cancer types. Because this analysis shows association rather than direction, both AKAP12-to-partner and partner-to-AKAP12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C6orf118 grouped by AKAP12-low versus AKAP12-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP12→partner) and Y-score (partner→AKAP12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C6orf118 →	+0.053	+3.450	<.001	.004	3	2
BLOOD_Leukemia	SPO11 →	+0.013	+3.969	<.001	.009	3	2
CNS	GPR152 →	+0.064	+4.000	<.001	.004	3	2
LARGE_INTESTINE	FBXO6 →	+1.028	+2.364	.001	<.001	3	2
LARGE_INTESTINE	CENPC →	+0.520	+2.364	.001	<.001	3	2
LARGE_INTESTINE	C1QTNF2 →	+0.247	+1.837	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 616 associations by consensus.

C6orf118 by AKAP12 expression — BLOOD_Leukemia

Explore this box plot interactively →