AKAP11

Across TCGA pan-cancer cohorts, AKAP11 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated AKAP11 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher AKAP11 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated AKAP11 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

UCEC, LUAD, and LSCC are the cancer types where AKAP11 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.469	0.944	.003	70	view →
LUAD	DFS	Median	All	0.957	0.876	.005	10	view →
LSCC	DFS	Quartile	II,III,IV	0.501	0.899	.007	7	view →
PDAC	OS	Quartile	III,IV	0.842	0.283	.020	3	view →
GBM	OS	Median	All	0.766	0.857	.033	1	view →
HNSC	DFS	Median	All	0.707	0.837	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

AKAP11–UCEC (DFS)

Open the UCEC breakdown →