AKAP1

Across TCGA pan-cancer cohorts, AKAP1 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated AKAP1 data layer compared with 19 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher AKAP1 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated AKAP1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LIHC show a favorable association.

UCEC, CESC, and BLCA are the cancer types where AKAP1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.956	0.621	.003	36	view →
CESC	OS	Median	II,III,IV	0.058	0.837	<.001	30	view →
BLCA	OS	Median	All	0.082	0.688	<.001	30	view →
LUSC	OS	Median	II,III,IV	0.182	0.615	.022	12	view →
ESCA	OS	Median	II,III,IV	0.250	0.550	.016	12	view →
LIHC	DFS	Median	III,IV	1.000	0.169	.044	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

AKAP1–UCEC (DFS)

Open the UCEC breakdown →