AKAP1

Across TCGA patient cohorts, AKAP1 mutation is significantly associated with the RNA expression of many other genes, with 3,680 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKAP1-associated genes across cancer lineages are NSMF, LINC02438, and NDUFA8. Each is linked with AKAP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both AKAP1-to-partner and partner-to-AKAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NSMF grouped by AKAP1-low versus AKAP1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP1→partner) and Y-score (partner→AKAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	NSMF →	+0.543	+3.006	.007	<.001	3	3
UCEC	LINC02438 →	+0.551	+1.860	<.001	<.001	3	3
UCEC	NDUFA8 →	+0.308	+2.094	<.001	<.001	3	3
UCEC	IMPA2 →	+0.635	+3.031	<.001	<.001	3	3
LIHC	MIR6077 →	+0.469	+5.447	<.001	.005	3	2
BRCA	DUX4L8 →	+0.023	+8.057	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,680 associations by consensus.

NSMF by AKAP1 expression — SKCM

Explore this box plot interactively →