AKAP1

Across TCGA cell cohorts, AKAP1 mutation is significantly associated with the RNA expression of many other genes, with 1,948 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AKAP1-associated genes across cancer lineages are ADGRA1, LRRC3C, and PPDPFL. Each is linked with AKAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AKAP1-to-partner and partner-to-AKAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADGRA1 grouped by AKAP1-low versus AKAP1-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP1→partner) and Y-score (partner→AKAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ADGRA1 →	+0.006	+4.807	<.001	.006	3	2
BLOOD_Leukemia	LRRC3C →	+0.087	+3.796	<.001	.008	3	2
KIDNEY	PPDPFL →	+0.165	+4.121	.003	.006	3	1
KIDNEY	OR2V1 →	+0.023	+4.491	.001	.002	3	1
BLOOD_Myeloma	TMEM61 →	+1.126	+4.807	.001	.006	3	1
BLOOD_Myeloma	AQP12A →	+0.076	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,948 associations by consensus.

ADGRA1 by AKAP1 expression — BLOOD_Myeloma

Explore this box plot interactively →