AK9

Across TCGA patient cohorts, AK9 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AK9-associated genes across cancer lineages are 4E-BP1, FASN, and PKC-delta_pS664. Each is linked with AK9 in more than 3 cancer types. Because this analysis shows association rather than direction, both AK9-to-partner and partner-to-AK9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by AK9-low versus AK9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AK9→partner) and Y-score (partner→AK9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.282	+2.137	<.001	<.001	3	4
UCEC	FASN →	+0.252	+1.362	.013	.031	3	4
UCEC	PKC-delta_pS664 →	-0.077	-1.440	.013	.020	3	4
COAD	PKC-a →	-0.350	-2.584	.001	.010	3	3
COAD	Caspase-7-cleavedD198 →	+1.215	+2.915	<.001	<.001	3	3
COAD	p27_pT157 →	+0.265	+1.708	<.001	.026	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

4E-BP1 by AK9 expression — UCEC

Explore this box plot interactively →