AK8

Across TCGA patient cohorts, AK8 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AK8-associated genes across cancer lineages are 14-3-3_beta, ACC_pS79, and ACC1. Each is linked with AK8 in more than 1 cancer types. Because this analysis shows association rather than direction, both AK8-to-partner and partner-to-AK8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by AK8-low versus AK8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AK8→partner) and Y-score (partner→AK8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.112	-2.794	.011	.003	3	1
UCEC	ACC_pS79 →	+0.332	+2.115	.028	.019	3	1
UCEC	ACC1 →	+0.407	+3.013	.010	.018	3	1
UCEC	Heregulin →	-0.106	-2.321	.048	.034	3	1
UCEC	Rad50 →	-0.226	-2.115	.033	.019	3	1
UCEC	S6_pS240_S244 →	+0.520	+2.807	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

14-3-3_beta by AK8 expression — UCEC

Explore this box plot interactively →