AK8

Across TCGA cell cohorts, AK8 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,717 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible AK8-associated GO terms across cancer lineages are Lysosomal lumen acidification, Sodium ion transmembrane transport, and Vesicle targeting, rough ER to cis-Golgi. Each is linked with AK8 in more than 9 cancer types. Because this analysis shows association rather than direction, both AK8-to-partner and partner-to-AK8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lysosomal lumen acidification grouped by AK8-low versus AK8-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AK8→partner) and Y-score (partner→AK8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Lysosomal lumen acidification →	+0.099	+0.602	<.001	<.001	3	10
CNS	Sodium ion transmembrane transport →	-0.055	-0.441	<.001	<.001	3	10
STOMACH	Vesicle targeting, rough ER to cis-Golgi →	+0.092	+0.619	.004	.005	3	10
STOMACH	Regulation of syncytium formation by plasma membrane fusion →	+0.104	+0.588	.001	.006	3	10
OVARY	Regulation of myoblast fusion →	+0.104	+0.617	<.001	<.001	3	10
STOMACH	Regulation of organelle assembly →	+0.049	+0.617	.005	.005	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,717 associations by consensus.

Lysosomal lumen acidification by AK8 expression — OESOPHAGUS

Explore this box plot interactively →