AK8

Across TCGA cell cohorts, AK8 mutation is significantly associated with the drug of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AK8-associated genes across cancer lineages are Sinularin, EHT-1864, and KIN001-042. Each is linked with AK8 in more than 1 cancer types. Because this analysis shows association rather than direction, both AK8-to-partner and partner-to-AK8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sinularin grouped by AK8-low versus AK8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AK8→partner) and Y-score (partner→AK8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Sinularin →	+0.352	+3.000	.017	.017	3	1
LARGE_INTESTINE	EHT-1864 →	+0.387	+2.807	.015	.046	2	1
LARGE_INTESTINE	KIN001-042 →	+0.224	+2.874	.044	.021	2	1
LARGE_INTESTINE	Ara-G →	+0.166	+2.944	.038	.018	2	1
LARGE_INTESTINE	Lestaurtinib →	+0.516	+2.932	.028	.019	1	1
LARGE_INTESTINE	BI-2536 →	+0.874	+2.871	.015	.021	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Sinularin by AK8 expression — LARGE_INTESTINE

Explore this box plot interactively →