AK7

Across TCGA patient cohorts, AK7 mutation is significantly associated with the RNA expression of many other genes, with 2,641 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AK7-associated genes across cancer lineages are LSM3, EIF4BP1, and MIR190A. Each is linked with AK7 in more than 2 cancer types. Because this analysis shows association rather than direction, both AK7-to-partner and partner-to-AK7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LSM3 grouped by AK7-low versus AK7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AK7→partner) and Y-score (partner→AK7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LSM3 →	+0.405	+1.999	.003	<.001	3	3
CESC	EIF4BP1 →	+0.153	+4.409	<.001	.006	3	2
LGG	MIR190A →	+0.507	+5.392	<.001	.005	3	2
LGG	LINC02632 →	+0.012	+5.392	.001	.005	3	2
LGG	RPS29P1 →	+0.296	+5.846	<.001	.003	3	2
LGG	NDUFB5P1 →	+0.135	+5.206	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,641 associations by consensus.

LSM3 by AK7 expression — UCEC

Explore this box plot interactively →