AK7

Across TCGA patient cohorts, AK7 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AK7-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and PCNA. Each is linked with AK7 in more than 1 cancer types. Because this analysis shows association rather than direction, both AK7-to-partner and partner-to-AK7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by AK7-low versus AK7-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AK7→partner) and Y-score (partner→AK7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.307	+2.815	.002	.036	3	2
UCEC	14-3-3_beta →	-0.085	-2.088	.011	.016	3	2
UCEC	PCNA →	+0.212	+2.201	.003	<.001	3	2
UCEC	PDCD4 →	-0.449	-1.755	.004	.013	3	2
UCEC	Rab25 →	-0.268	-1.321	.015	.029	3	2
UCEC	C-Raf →	+0.122	+1.321	.011	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Caspase-7-cleavedD198 by AK7 expression — COAD

Explore this box plot interactively →