Q-omics provides the consensus-scored AK4P4 profile across patient tissues and cancer cell-line models. AK4P4 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, AK4P4 is differentially expressed in 10, with the highest sampling consensus in THCA. Additionally, AK4P4 RNA expression shows 11,157 significant gene co-expression associations, with the highest sampling consensus in DLBC. Together, these results highlight UVM, THCA, and DLBC as cancer lineages where AK4P4 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for AK4P4 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes AK4P4 survival associations across molecular data types. AK4P4 RNA expression shows survival associations in the most cancer types (24). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible AK4P4 RNA expression–survival associations across cancer types. High AK4P4 expression shows unfavorable associations in UVM, LUSC and UCEC, but favorable associations in BLCA, LUAD and READ. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .011). Together, the overview and detailed table identify UVM as the clearest survival context for AK4P4 RNA expression.
This table summarizes AK4P4 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for AK4P4. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. AK4P4 shows lower tumor expression in THCA, KICH, READ and LUSC and higher tumor expression in CHOL and PRAD. The THCA box plot shows higher AK4P4 RNA expression in normal versus tumor tissue (log2 FC = −0.173, t-test p = .001).
This table shows molecular features associated with AK4P4 in patient tissues and cancer cell lines. In patient samples, AK4P4 shows the broadest associations at the RNA and protein expression levels, with DLBC recurring as the lineage with the largest associated feature set.
