AK4P3

Across TCGA pan-cancer cohorts, AK4P3 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of AK4P3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where AK4P3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types AK4P3 is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

HNSC, LUAD, and COAD are the cancer types where AK4P3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AK4P3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.198	.010	7	view →
LUAD	Male	All	+0.286	<.001	5	view →
COAD	All	All	+0.281	.002	4	view →
LUSC	All	All	+0.203	<.001	4	view →
KIRP	Male	All	−0.298	.004	2	view →
KICH	Female	All	−0.237	.023	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

AK4P3–HNSC

Open the HNSC breakdown →