AK4

Across TCGA pan-cancer cohorts, AK4 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated AK4 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher AK4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated AK4 expression acts as an unfavorable survival marker, although some lineages such as COAD and LSCC show a favorable association.

CCRCC, COAD, and HNSC are the cancer types where AK4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.600	0.915	<.001	22	view →
COAD	DFS	Tertile	All	1.000	0.915	.047	12	view →
HNSC	OS	Median	All	0.484	1.000	.038	12	view →
LUAD	OS	Median	All	0.670	0.845	.016	9	view →
LSCC	DFS	Quartile	II,III,IV	0.928	0.499	.003	7	view →
GBM	OS	Quartile	All	0.911	0.759	.015	1	view →
PDAC	DFS	Median	All	0.712	0.868	.029	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

AK4–CCRCC (DFS)

Open the CCRCC breakdown →