AK4

Across TCGA patient cohorts, AK4 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AK4-associated genes across cancer lineages are eEF2, EGFR_pY1068, and eIF4E. Each is linked with AK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both AK4-to-partner and partner-to-AK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by AK4-low versus AK4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AK4→partner) and Y-score (partner→AK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.445	+2.000	.005	.032	3	1
UCEC	EGFR_pY1068 →	-0.358	-3.459	.001	.005	3	1
UCEC	eIF4E →	+0.207	+3.013	.029	.018	3	1
UCEC	A-Raf_pS299 →	-0.144	-3.169	.007	.019	3	1
UCEC	HER3_pY1289 →	+0.079	+2.026	.041	.018	3	1
UCEC	INPP4B →	-0.299	-1.986	.040	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

eEF2 by AK4 expression — UCEC

Explore this box plot interactively →