AK3

Across TCGA pan-cancer cohorts, AK3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated AK3 data layer compared with 21 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher AK3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated AK3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and OV show a favorable association.

LSCC, UCEC, and LUAD are the cancer types where AK3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	III,IV	0.422	1.000	.026	9	view →
UCEC	OS	Quartile	II,III,IV	0.519	1.000	.027	8	view →
LUAD	OS	Tertile	III,IV	0.422	0.879	.024	5	view →
HNSC	DFS	Quartile	III,IV	0.940	0.572	.013	5	view →
OV	DFS	Tertile	All	1.000	0.801	.047	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

AK3–LSCC (DFS)

Open the LSCC breakdown →