AK3

Across TCGA patient cohorts, AK3 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AK3-associated genes across cancer lineages are 4E-BP1, 14-3-3_beta, and MEK1. Each is linked with AK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both AK3-to-partner and partner-to-AK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by AK3-low versus AK3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AK3→partner) and Y-score (partner→AK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.298	+3.029	.018	.018	3	2
UCEC	14-3-3_beta →	-0.120	-3.143	.010	.018	3	1
UCEC	MEK1 →	+0.533	+3.459	.001	.005	3	1
UCEC	Rictor_pT1135 →	-0.130	-2.999	.006	.035	3	1
UCEC	Caspase-8 →	-0.238	-3.143	.042	.018	3	1
UCEC	CDK1_pY15 →	+0.198	+2.829	.049	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

4E-BP1 by AK3 expression — UCEC

Explore this box plot interactively →