AK3

Across TCGA cell cohorts, AK3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,396 significant associations in total. BONE shows the largest number of these associations.

The most reproducible AK3-associated GO terms across cancer lineages are ADP biosynthetic process, Purine nucleoside diphosphate biosynthetic process, and Purine ribonucleoside diphosphate biosynthetic process. Each is linked with AK3 in more than 15 cancer types. Because this analysis shows association rather than direction, both AK3-to-partner and partner-to-AK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADP biosynthetic process grouped by AK3-low versus AK3-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AK3→partner) and Y-score (partner→AK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ADP biosynthetic process →	+0.190	+0.755	<.001	<.001	3	16
LUNG_SCLC	Purine nucleoside diphosphate biosynthetic process →	+0.209	+1.149	<.001	.001	3	15
LUNG_SCLC	Purine ribonucleoside diphosphate biosynthetic process →	+0.209	+1.149	<.001	.001	3	15
BONE	Positive regulation of neutrophil activation →	+1.336	+1.433	<.001	<.001	3	14
URINARY_TRACT	ITP metabolic process →	+0.136	+1.278	<.001	<.001	3	11
BONE	UTP metabolic process →	+0.136	+1.286	.003	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,396 associations by consensus.

ADP biosynthetic process by AK3 expression — LARGE_INTESTINE

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