AK2

Across TCGA patient cohorts, AK2 mutation is significantly associated with the immune_cell of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AK2-associated genes across cancer lineages are Erythrocytes, mv Endothelial cells, and Th2 cells. Each is linked with AK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AK2-to-partner and partner-to-AK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Erythrocytes grouped by AK2-low versus AK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AK2→partner) and Y-score (partner→AK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Erythrocytes →	+0.036	+2.180	.001	.034	3	1
UCEC	mv Endothelial cells →	-0.024	-3.321	.021	.010	3	1
UCEC	Th2 cells →	+0.207	+3.592	.010	.001	3	1
UCEC	Endothelial cells →	-0.039	-3.161	.022	.019	2	1
UCEC	lymphatic Endothelial cells →	-0.027	-3.419	.010	.005	2	1
SKCM	Melanocytes →	+0.088	+2.839	.016	.035	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Erythrocytes by AK2 expression — UCEC

Explore this box plot interactively →