AK2

Across TCGA cell cohorts, AK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,764 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible AK2-associated GO terms across cancer lineages are Mitotic DNA replication checkpoint signaling, DNA replication initiation, and DNA replication checkpoint signaling. Each is linked with AK2 in more than 13 cancer types. Because this analysis shows association rather than direction, both AK2-to-partner and partner-to-AK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic DNA replication checkpoint signaling grouped by AK2-low versus AK2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AK2→partner) and Y-score (partner→AK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Mitotic DNA replication checkpoint signaling →	+0.147	+0.784	<.001	<.001	3	14
BONE	DNA replication initiation →	+0.205	+0.710	.003	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	DNA replication checkpoint signaling →	+0.169	+0.834	<.001	<.001	3	13
BREAST	RISC complex assembly →	+0.113	+0.988	<.001	<.001	3	13
SOFT_TISSUE	Positive regulation of mitotic cell cycle phase transition →	+0.116	+0.638	<.001	.002	3	12
SOFT_TISSUE	Nuclear pore localization →	+0.128	+0.643	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,764 associations by consensus.

Mitotic DNA replication checkpoint signaling by AK2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →