AK1

Across TCGA pan-cancer cohorts, AK1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated AK1 data layer compared with 22 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher AK1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated AK1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, LUAD, and LSCC are the cancer types where AK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	All	1.000	0.555	<.001	60	view →
LUAD	OS	Tertile	II,III,IV	0.866	0.300	.006	18	view →
LSCC	OS	Median	All	0.923	1.000	.012	6	view →
PDAC	OS	Median	IV	0.491	0.836	.024	3	view →
HNSC	DFS	Median	III,IV	1.000	0.939	.043	1	view →
GBM	OS	Median	All	0.774	0.933	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

AK1–CCRCC (DFS)

Open the CCRCC breakdown →