AK1

Across TCGA patient cohorts, AK1 mutation is significantly associated with the total protein of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AK1-associated genes across cancer lineages are JNK2 and MEK1. Each is linked with AK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AK1-to-partner and partner-to-AK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by AK1-low versus AK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AK1→partner) and Y-score (partner→AK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.250	+3.169	.021	.020	1	1
UCEC	MEK1 →	+0.437	+3.169	.029	.020	1	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

JNK2 by AK1 expression — UCEC

Explore this box plot interactively →