AJUBA

Across TCGA patient cohorts, AJUBA mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AJUBA-associated genes across cancer lineages are Notch1, PCNA, and Rab11. Each is linked with AJUBA in more than 1 cancer types. Because this analysis shows association rather than direction, both AJUBA-to-partner and partner-to-AJUBA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by AJUBA-low versus AJUBA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AJUBA→partner) and Y-score (partner→AJUBA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.252	+3.169	.001	.020	3	1
UCEC	PCNA →	+0.335	+3.169	.004	.020	3	1
UCEC	Rab11 →	-0.208	-3.169	.009	.020	3	1
UCEC	VHL →	-0.942	-3.169	.011	.020	3	1
UCEC	Caspase-7-cleavedD198 →	+0.669	+3.169	.040	.020	3	1
UCEC	C-Raf →	+0.299	+3.169	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Notch1 by AJUBA expression — UCEC

Explore this box plot interactively →