AJM1

Across TCGA patient cohorts, AJM1 mutation is significantly associated with the RNA expression of many other genes, with 633 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AJM1-associated genes across cancer lineages are MIR3689B, RNA5SP319, and RNU6-1311P. Each is linked with AJM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both AJM1-to-partner and partner-to-AJM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3689B grouped by AJM1-low versus AJM1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AJM1→partner) and Y-score (partner→AJM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR3689B →	+0.378	+6.309	<.001	.001	3	3
UCEC	RNA5SP319 →	+0.491	+2.324	.001	.009	3	2
UCEC	RNU6-1311P →	+0.528	+3.379	<.001	.001	3	2
UCEC	TUBB4BP2 →	+0.210	+3.666	.006	.001	3	2
UCEC	FXYD6P2 →	+0.211	+3.084	.002	<.001	3	2
UCEC	RN7SL546P →	+0.426	+3.565	.007	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 633 associations by consensus.

MIR3689B by AJM1 expression — LUSC

Explore this box plot interactively →