AJM1

Across TCGA cell cohorts, AJM1 mutation is significantly associated with the RNA expression of many other genes, with 588 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AJM1-associated genes across cancer lineages are ACER1, DEFB108B, and GPRIN2. Each is linked with AJM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AJM1-to-partner and partner-to-AJM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACER1 grouped by AJM1-low versus AJM1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AJM1→partner) and Y-score (partner→AJM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACER1 →	+0.061	+2.185	<.001	<.001	3	2
BLOOD_Leukemia	DEFB108B →	+0.089	+3.269	<.001	.007	3	2
BLOOD_Leukemia	GPRIN2 →	+0.029	+3.345	<.001	.009	3	2
URINARY_TRACT	GABRA4 →	+0.024	+4.217	<.001	.005	3	1
URINARY_TRACT	OR1C1 →	+0.020	+4.217	<.001	.005	3	1
LARGE_INTESTINE	DEPDC5 →	+0.439	+2.459	.009	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 588 associations by consensus.

ACER1 by AJM1 expression — LARGE_INTESTINE

Explore this box plot interactively →